Insights

RNA Processing at the MNDA Symposium on ALS/MND


Around the time I first started working in Sheffield in 2008 it was discovered that an RNA processing protein called TDP-43 is a key component of brain pathology in the majority of motor neuron disease (MND) / amyotrophic lateral sclerosis (ALS).  Following that finding the importance of RNA processing to our understanding of the disease pathogenesis…… Continue reading RNA Processing at the MNDA Symposium on ALS/MND

Insights · Scientific

SESSION 3A RNA PROCESSING AND DYSREGULATION


The importance of RNA processing in ALS has been well established by the discovery of pathogenic mutations in key RNA processing proteins, most notably TDP-43 which is abnormally aggregated in neurons of almost all patients.  This session described work by a number of groups attempting to characterise the mechanisms associated with RNA processing in ALS…… Continue reading SESSION 3A RNA PROCESSING AND DYSREGULATION