2014 · 2014 International Symposium - Brussels · Scientific

Session 4A Autophagy


Growing evidence suggests dysregulated autophagy contributes toward several neurodegenerative diseases, including ALS and FTD. In the session 7A – genetics and genomics, Professor John Hardy from University College London highlighted that many ALS causing mutations occur in genes that regulate autophagy. In addition, accumulation of misfolded protein in motor neurons is a pathological hallmark of…… Continue reading Session 4A Autophagy

2014 · 2014 International Symposium - Brussels · Clinical · Healthcare · Insights

Respiratory Management in ALS – Session 8B from Brussels


Discussion of respiratory management in caring for ALS patients is essential for their comfort, health and end-of-life decisions. This session covered a range of information from original diagnosis of respiratory failure, use of a diaphragm pacing system and experiences of termination or failure of ventilation from the perspectives of health professionals working in ALS centres…… Continue reading Respiratory Management in ALS – Session 8B from Brussels

Insights · Scientific

How can we model ALS in the lab? – Session 5A – In Vitro Modelling


Modelling a complex condition such as ALS in a laboratory is an understandably difficult concept, and it is perhaps unsurprising that we don’t yet have the perfect model.  This session early on a Saturday morning looked at the different approaches to using cells in the lab to investigate ALS. The first speaker and one of…… Continue reading How can we model ALS in the lab? – Session 5A – In Vitro Modelling

2014 · 2014 International Symposium - Brussels · Insights · Scientific

Non-neuronal cells – A final symposium report


The last scientific session for the symposium was on non-neuronal cells and comprised of speakers from around the world. Professor Hugh Perry (Southampton, UK) gave the first presentation. He discussed the commonality between various neurodegenerative diseases and the role inflammation, microglia and macrophages play. In neurodegeneration, microglia proliferate and are primed by the molecules CSF-1…… Continue reading Non-neuronal cells – A final symposium report

2014 · 2014 International Symposium - Brussels · Insights · Scientific

Murine models – A report from Brussels


Linda Greensmith from UCL, UK and Bradley Turner from the Florey Institute, Australia chaired one of the final sessions for Saturday on Murine Models. With the number of causative genes increasing over the last 20 years it is critical to understand the disease mechanism for each gene to progress understanding of the disease and more…… Continue reading Murine models – A report from Brussels