The importance of RNA processing in ALS has been well established by the discovery of pathogenic mutations in key RNA processing proteins, most notably TDP-43 which is abnormally aggregated in neurons of almost all patients. This session described work by a number of groups attempting to characterise the mechanisms associated with RNA processing in ALS…… Continue reading SESSION 3A RNA PROCESSING AND DYSREGULATION
Although the underlying cause of sALS remains a mystery, there is a rapidly growing list of genes in which mutations have been implicated in ALS (fALS; accounting for 5-10% of all ALS cases). A subset of these genes have been associated with either protein aggregates found in motor neurones (e.g. SOD1, TDP-43, FUS, VAPB), protein…… Continue reading Session 10A Protein processing and degradation
The sessions we attended today at the 24th international symposium included autonomy and quality of life, cognitive and psychological change. Hogden, from Australia described a decision making model which was originally used in cancer care. She highlighted that there were lots of important decisions that patients need to make but these are made more difficult…… Continue reading Day one of ALS Symposium
Wow what a day! The MND clinic girls from Notts have been inspired with what we have heard today. Amber Ward OT from USA and Mel Holmes OT from Australia, talked about the wonders of velcro for example how to secure your communication aid to your lap to prevent it slipping . They also described…… Continue reading Our highlights of the Allied Professionals Forum
The MND clinic girls from Nottingham have arrived in Milan and are looking forward to a day of learning and networking. We are particularly looking forward to the presentations on multidisciplinary working, AAC apps and decision making for enteral nutrition in ALS/MND.