Firstly, Dr Cathleen Lutz (The Jackson Laboratory, USA) discussed the range of current mouse models of MND and the potential for generating new models. Lutz explored the many reasons why MND is a hard disease to model, and how the SOD1-G93A model has become the ‘workhorse’ for MND mouse modelling. However, as subgroups and new…… Continue reading Session 4A: Disease Models
Motor neurone disease (MND) can cause weakness in the chest muscles involved in breathing. This leads to shortness of breath and symptoms including disturbed sleep and headaches. Ventilation support allows a person to breathe more efficiently and can also extend survival. The MND Association has funded research into respiratory management and ventilation support for people…… Continue reading Withdrawal of ventilation support at the request of a patient: the ethical, moral and legal issues
Leonard Petruccelli commenced the session discussing mechanisms of toxicity and therapeutic approaches for C9FTD/ALS, beginning by highlighting the enormous advancement in the understanding of the genetics and neuropathology of FTD and ALS since 2006. The three proposed mechanism of C9orf72 mutations were presented; 1) a gain of toxicity as a result of RNA foci in…… Continue reading C9orf72 and novel therapeutics: report from ENCALS Friday 22nd May 2015 – Oral Session 3
Yesterday I attended the Engineering and Physical Sciences Research (EPSRC) Council’s Town Hall meeting about their Healthcare Technologies ‘Grand Challenges’. These ‘Grand Challenges’ form part of their recently-announced new strategy for their Healthcare Technologies theme. The aim of the meeting was to outline the new strategy and to raise awareness of some new opportunities to begin to…… Continue reading Could funding from the EPSRC help your MND research?
This was my first time at the MNDA symposium and I was excited at the thought of getting to put faces to names of those whose papers I have read! On arriving at the conference centre on the first day in Brussels I was amazed at the number of people who had travelled from all…… Continue reading 25th International Symposium on ALS/MND: a report from the Protein Misfolding and Toxicity session